User:David Waugh

Dr. Waugh graduated from Yale University in 1982 with a B.S. in Molecular Biophysics & Biochemistry. He received his Ph.D. in Biochemistry & Molecular Biology from Indiana University in 1989, under the direction of Dr. Norman Pace. His doctoral dissertation, entitled "Mutational Analysis of Catalytic Function in Ribonuclease P RNA", earned him the Esther L. Kinlsey award for the outstanding Ph.D. dissertation presented to the Graduate School at Indiana University in 1989. During 1990 and 1991 he was a postdoctoral fellow in Dr. Robert Sauer's laboratory at the Massachusetts Institute of Technology, where he studied structure-function relationships in the type IIS restriction endonuclease FokI. In 1991, Dr. Waugh joined the Biomolecular Structure Group at Hoffmann-La Roche, as head of the Macromolecular Engineering Laboratory. He became a principal investigator at the National Cancer Institute in 1996 and gained tenure as a Senior Investigator in 2005. Dr. Waugh currently heads the Protein Engineering Section in the Macromolecular Crystallography Laboratory at the NCI. His research interests revolve around methods development for high-throughput protein expression and purification and X-ray crystallographic studies of virulence factors from potential agents of bioterrorism, especially Yersinia pestis. He has received Federal Technology Transfer awards every year since 2005. Dr. Waugh is an affiliate of the Northeast Structural Genomics Consortium and has also served on the external scientific advisory boards for the Berkeley Structural Genomics Center and the Structural Genomics of Pathogenic Protozoa Project. He is a member of the structural genomics section of the Faculty of 1000 literature awareness service and currently serves on the editorial board for the journal Protein Expression and Purification.